Colorado Proposition 122 and the Natural Medicine Health Act
How Colorado's natural medicine program works, who licenses healing centers, and how it differs from Oregon's model.
What Prop. 122 did
In 2022, Colorado voters passed Proposition 122, the Natural Medicine Health Act. It did two things at once: it decriminalized personal use of certain natural medicines for adults 21+, and it directed the state to build a licensed access program similar to Oregon's.
The regulated program
The Colorado Department of Revenue's Natural Medicine Division began accepting business license applications on December 31, 2024. It licenses healing centers, cultivations, manufacturers, and testing facilities. Facilitators are licensed separately by the Department of Regulatory Agencies (DORA).
The first healing center license was issued in early 2025. As of 2026, there are roughly 25–30 licensed healing centers operating across the state.
What's covered
Prop. 122 initially covers psilocybin and psilocyn. The Natural Medicine Advisory Board has authority to recommend adding DMT, ibogaine, and mescaline (excluding peyote) starting in 2026.
Personal use vs. regulated use
Unlike Oregon, Colorado decriminalized personal possession, gifting (without remuneration), and home cultivation for adults 21+. You still cannot legally sell natural medicine outside the regulated program.
How healing centers differ from Oregon service centers
- Tiers: Colorado offers a "micro-healing center" license with smaller on-site storage limits.
- Setting: Many Colorado healing centers are integrated with existing wellness, acupuncture, or therapy practices.
- Travel: There is no residency requirement.
Mushy Guide only lists Colorado healing centers that appear on the DOR Natural Medicine Division's licensee map or are reported as licensed by reputable local press.
Questions & answers
4 answeredThe most common questions we hear on this topic.
Is it legal to grow psilocybin mushrooms at home in Colorado?
Prop. 122 decriminalized personal cultivation, possession, and non-commercial sharing for adults 21+. It is still a federal offense, and sale outside the regulated program remains illegal under state law.
Can I just walk into a Colorado healing center and buy mushrooms?
No. Healing centers administer supervised sessions on site, similar to Oregon. They do not sell take-home product.
How is Colorado's program different from Oregon's?
Colorado decriminalized personal use in addition to creating a licensed program, offers a smaller 'micro-healing center' tier, and licenses facilitators through DORA rather than the same agency that licenses businesses.
When will DMT, ibogaine, and mescaline be added?
The Natural Medicine Advisory Board can recommend adding them starting in 2026. Any expansion has to go through rulemaking; nothing is automatic.